Dr SAVITHA S SHARMA

Ph.D

Senior Scientist

Doctor's Message 

Nature is brimming with secrets awaiting to be discovered! Your imagination, combined with hardwork, is the the key to unlocking this treasure.

Languages spoken 

English, Kannada, Hindi, Tulu

Areas of Interest 

1. My long-term goals are to understand mechanisms of cellular proliferation and differentiation in normal physiology and cancer, with an aim of finding new therapeutic avenues to target tumorigenesis, metastasis, and drug resistance. 2. My current research focuses on elucidating the functions of atypical cyclins in cancer development or progression. In addition, I am also interested in biomarker discovery and validation, particularly from the angle of improving early cancer diagnosis. 3. To gain mechanistic insights, my research combines the use of cell-line models, biochemical approaches, functional genomics, proteomics, and metabolomics.

Publications

(1)SS Sharma, WJ Pledger, P. Kondaiah (2022). The deubiquitylase USP7 is a novel cyclin F-interacting protein and regulates cyclin F protein stability independent of deubiquitylase activity. Submitted.
(2)W Fu, SS Sharma, L Ma, B Chu, MM Bui, D Reed, WJ Pledger (2013). Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor. Cell death & disease 4: e566-e566
(3)TK Bagui, SS Sharma, L Ma, WJ Pledger (2013). Proliferative status regulates HDAC11 mRNA abundance in nontransformed fibroblasts. Cell Cycle 12: 3433-3441.
(4)SS Sharma, L Ma, TK Bagui, KD Forinash, WJ Pledger (2012). A p27 Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation. Oncogene 31: 3989-3998.
(5)D Nalbant, H Youn, SI Nalbant, S Sharma, E Cobos, EG Beale, Y Du, SC Williams (2005). FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. BMC genomics 6: 1-21

Hobbies

Photography, Painting, Poetry