Shankara Cancer Hospital Bangalore Best

 Research at
Sri Shankara Cancer Foundation

At Sri Shankara Cancer Foundation, we firmly believe that the strongest weapon in fighting cancer is the sound understanding and knowledge of cancer. In order to improve this understanding of cancer through a scientific approach, the foundation has set up state-of-the-art research facilities, which undertake cutting edge research in the field of oncology. Sri Shankara Cancer Foundation is recognized by the Department of Scientific and Industrial Research, Government of India, as a Scientific and Industrial Research Organization (DSIR - SIRO)

 

RESEARCH AREAS

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CLINICAL RESEARCH

Sri Shankara Cancer Hospital and Researc

BASIC AND TRANSLATIONAL RESEARCH

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PREVENTIVE & COMMUNITY ONCOLOGY RESEARCH

RESEARCH INFRASTRUCTURE

The research laboratory is located in our dedicated research block - Sri Sharada Kripa. The state of the art laboratory houses the latest, cutting edge technology in oncological research, including Mass Spectromtery, Next Generation Sequencing (NGS), Sanger Sequencer, Real Time PCR (RT-PCR), Fluoroscence In Situ Hybridization (FISH) and Immuno Histo Chemistry (IHC).

Our Tumour Bio Bank can store upto 15,000 samples along with the blood sample. A dedicated scientist is responsible for the Bio Bank. Fresh tissues from all cancers are anonymized, coded and stored in the Bio Bank. 

Sri Shankara Cancer Hospital & Research Centre is a member of the Indian Cancer Genome Atlas (ICGA) 

and has collaborations with

 

Systems and Precision Cancer Medicine Team - Institute of Cancer Research, UK 

University of Nottinghamm, UK

Indian Council of Medical Research

Indian Institute of Sciences, Bangalore,

National Cancer Grid

The team at Sri Shankara National Centre for Cancer Prevention and Research are enabled to conduct community, preventive, economic and epidemiological research through customized technology including  a custom built, satellite enabled mobile cancer units.

 

RESEARCH FACULTY

3 Senior Post Doctoral Scientists guide the research projects conducted in collaboration with Clinical Faculty attached to Sri Shankara Cancer Hospital and Research Centre. 

The staff of the research centre include 6 research associates and a Bio Informatician. 

The insitute proposes to induct 3 more post doctoral scientists to expand the research activity. 

 
 

RESEARCH PROJECTS

Sri Shankara Cancer Foundation's efforts towards understanding cancer, improving treatment outcomes and developing interventions to prevent cancer are focused on some of the most common cancers in the Indian population. This includes Ovarian Cancers, Breast Cancers, Gastro-Intestinal Cancers, Lung, Head and Neck Cancers, Urinary Bladder Cancers and Blood cancers (Leukemias and Lymphomas).

With the guidance from eminent academicians and professionals in our Academic Advisory Board and Institutional Ethics Committee, research meetings are held every quarter to evaluate new and ongoing research projects. 

10

Completed projects

60

On Going Projects

05 

Collaborations

31

Publications

CONFERENCE PRESENTATIONS

Best presentation in National Surgeon’s conference (NATCON 2021)

PDL1 Expression in Oral Squamous Cell Carcinoma of the tongue and Buccoalveolar complex - Prognostic significance

Dr Thirumanikanthan, BS Srinath, Aruna Korlimarla, Hari PS, Rekha V Kumar

Presented virtually in San Antonio Breast Cancer Congress, Dec 2021

A novel combination of a 2 gene score and TIL as a predictive Biomarker for responders to novel therapies in Indian TNBC – A population with greater proportion of TNBCs

Aruna Korlimarla, Hari PS, Jyothi Prabhu, Chantirika Ragulan , Ravi B Diwakar, Sandhya Appachu, Maggie Cheang, Rekha V Kumar, BS Srinath, TS Sridhar, Anguraj Sadananadam

COMPLETED PROJECTS

  • Study on Cardiac Sparing Radiotherapy In Left Breast Carcinoma Patients - Dosimetric Comparison of Various Techniques

  • Pilot Study of Radiation Dose Escalation In The Treatment of Carcinoma Esophagus undergoing Concurrent Chemoradiation

  • Clinical pathological profiles of patients with triple negative breast carcinoma

  • Comparative study of palpation guided lumpectomy, ultrasound guided lumpectomy and cavity shaving technique for attaining negative margins in breast conservation surgery

  • Comparative Study of Dose to Small Bowel, Bone Marrow and Femur Between 3 Different Radiotherapy Techniques –3D Conformal Radiotherapy (3DCRT), Intensity Modulated Radiotherapy (IMRT) And Rotational Intensity Modulated Radiotherapy in The Treatment of Carcinoma Rectum

  • Comparison of RENAL, PADUA, ABC and C-index scoring systems in predicting perioperative outcomes after nephron sparing surgery

  • Prospective Study to compare the efficacy of topical Morphine mouth wash with standard Benzydamine oral mouth wash in the management of Oral mucositis in patients undergoing head and neck radiotherapy or Concurrent chemoradiotherapy

  • Pilot Study of the Role of Local Consolidative Radiotherapy Following Systemic Chemotherapy on Well Controlled Limited Metastatic Non Small Cell Lung Cancer

  • Comparison of Salivary Amylase levels, Salivary Scintigraphy and Diffusion Weighted Magnetic Resonance Imaging in evaluation of Xerostomia in Carcinoma of Nasopharynx, Oropharynx, Hypopharynx and Larynx patients treated with Intensity Modulated Radiotherapy

  • GlobalSurg – CovidSurg week: Determining the optimal timing for surgery following SARS – COV-2 infection  

 

PUBLICATIONS

Publ. Year
Title
Journal
Authors
Citation
2022
Comprehensive characterization of immune landscape of Indian and Western triple negative breast cancers
Translational Oncology
Aruna Korlimarla, Hari PS, Jyoti Prabhu, Chanthirika Ragulan, Yatish Patil, Snijesh VP, Krisha Desai, Aju Mathews, Sandhya Appachu, Ravi B. Diwakar, Srinath BS, Alan Melcher, Maggie Cheang, Anguraj Sadanandam
Transl Oncol. 2022 Aug 11;25:101511. doi: 10.1016/j.tranon.2022.101511. Epub ahead of print. PMID: 35964339.
2021
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids
Life Science Alliance
Jimpi Langthasa, Purba Sarkar, Shruthi Narayanan, Rahul Bhagat, Annapurna Vadaparty, Ramray Bhat
Life Sci Alliance. 2021 Aug 10;4(10):e202000942. doi: 10.26508/lsa.202000942. PMID: 34376568; PMCID: PMC8358442.
2021
Pre-Menopausal Women With Breast Cancers Having High AR/ER Ratios in the Context of Higher Circulating Testosterone Tend to Have Poorer Outcomes
Frontiers in Endocrinology
S Rajarajan A Korlimarla Annie Alexander, C. E. Anupama, R Ramesh, B. S. Srinath5, T. S. Sridhar and JS Prabhu
Front. Endocrinol., 21 June 2021 | https://doi.org/10.3389/fendo.2021.679756
2021
Preliminary clinical outcomes of patients treated with vaginal brachytherapy alone using multi-channel vaginal brachytherapy applicator in operated early-stage endometrial cancer
Rep Pract Oncol Radiother
Rishi KS, David S, Pathikonda M, Ramachandra P, Giri GV, Vadaparty A, Srinath BS.
Rep Pract Oncol Radiother. 2021 Feb 25;26(1):43-49. doi: 10.5603/RPOR.a2021.0007. eCollection 2021.
2020
Single Institution Experience of Postoperative Electron Beam Radiation Therapy in the Treatment of Keloids
Adv Radiat Oncol
Rishi KS, Sarkar N, Kesari P, Pathikonda M, Ramachandra P, Donapati PKR, Giri GV, Srinath BS.
Adv Radiat Oncol. 2020 Oct 21;6(2):100596. doi: 10.1016/j.adro.2020.10.009. eCollection 2021 Mar-Apr.
2020
A comparative study of perioperative techniques to attain negative margins and spare healthy breast tissue in breast conserving surgery
Breast Dis
Krishna KL, Srinath BS, Santosh D, Velusamy S, Divyamala KP, Sariya Mohammadi J, Kurpad V, Kulkarni S, Yaji P, Goud S, Dhanireddy S, Ram J.
Breast Dis. 2020;39(3-4):127-135. doi: 10.3233/BD-200443.
2020
An advisory by the association of radiation oncologists of India for radiation therapy patients and staff among COVID 19 pandemic
J Cancer Res Ther
Talapatra K, Gupta M, Singh K, Giri GV, Vashistha R.
J Cancer Res Ther. 2020 Apr-Jun;16(3):638-640. doi: 10.4103/jcrt.JCRT_687_20.
2020
miR-18a activates Wnt pathway in ER-positive breast cancer and is associated with poor prognosis
Cancer Med
Nair MG, Prabhu JS, Korlimarla A, Rajarajan S, P S H, Kaul R, Alexander A, Raghavan R, B S S, T S S.
Cancer Med. 2020 Aug;9(15):5587-5597. doi: 10.1002/cam4.3183. Epub 2020 Jun 16.
2020
Indian clinical practice consensus guidelines for the management of very advanced disease of squamous cell carcinoma of head and neck
Indian J Cancer
Prabhash K, Babu G, Chaturvedi P, Kuriakose M, Birur P, Anand AK, Kaushal A, Mahajan A, Syiemlieh J, Singhal M, Gairola M, Ramachandra P, Goyal S, John S, Nayyar R, Patil VM, Rao V, Roshan V, K RG.
Indian J Cancer. 2020 Feb;57(Supplement):S22-S25. doi: 10.4103/0019-509X.278977.
2020
Indian clinical practice consensus guidelines for the management of laryngeal cancer
Indian J Cancer
Singhal M, Prabhash K, Babu G, Chaturvedi P, Kuriakose M, Birur P, Anand AK, Kaushal A, Mahajan A, Syiemlieh J, Gairola M, Ramachandra P, Goyal S, John S, Nayyar R, Patil VM, Rao V, Roshan V, Rath GK.
Indian J Cancer. 2020 Feb;57(Supplement):S19-S21. doi: 10.4103/0019-509X.278973.
2020
Indian clinical practice consensus guidelines for the management of hypopharyngeal cancer
Indian J Cancer
Babu G, Prabhash K, Chaturvedi P, Kuriakose M, Birur P, Anand AK, Kaushal A, Mahajan A, Syiemlieh J, Singhal M, Gairola M, Ramachandra P, Goyal S, John S, Nayyar R, Patil VM, Rao V, Roshan V, Rath GK.
Indian J Cancer. 2020 Feb;57(Supplement):S16-S18. doi: 10.4103/0019-509X.278972.
2020
Indian clinical practice consensus guidelines for the management of oropharyngeal cancer
Indian J Cancer
Prabhash K, Babu G, Chaturvedi P, Kuriakose M, Birur P, Anand AK, Kaushal A, Mahajan A, Syiemlieh J, Singhal M, Gairola M, Ramachandra P, Goyal S, John S, Nayyar R, Patil VM, Rao V, Roshan V, Rath GK.
Indian J Cancer. 2020 Feb;57(Supplement):S12-S15. doi: 10.4103/0019-509X.278976.
2020
Indian clinical practice consensus guidelines for the management of oral cavity cancer
Indian J Cancer
Chaturvedi P, Prabhash K, Babu G, Kuriakose M, Birur P, Anand AK, Kaushal A, Mahajan A, Syiemlieh J, Singhal M, Gairola M, Ramachandra P, Goyal S, John S, Nayyar R, Patil VM, Rao V, Roshan V, Rath GK.
Indian J Cancer. 2020 Feb;57(Supplement):S6-S8. doi: 10.4103/0019-509X.278975.
2020
Indian clinical practice consensus guidelines for the management of squamous cell carcinoma of head and neck
Indian J Cancer
Prabhash K, Babu G, Chaturvedi P, Kuriakose M, Birur P, Anand AK, Kaushal A, Mahajan A, Syiemlieh J, Singhal M, Gairola M, Ramachandra P, Goyal S, John S, Nayyar R, Patil VM, Rao V, Roshan V, Rath GK.
Indian J Cancer. 2020 Feb;57(Supplement):S1-S5. doi: 10.4103/0019-509X.278971.
2019
Measurements and Monte Carlo calculation of radial dose and anisotropy functions of BEBIG (60)Co high-dose-rate brachytherapy source in a bounded water phantom
J Contemp Brachytherapy
Reddy BR, Chamberland MJP, Ravikumar M, Varatharaj C.
J Contemp Brachytherapy. 2019 Dec;11(6):563-572. doi: 10.5114/jcb.2019.91224. Epub 2019 Dec 25.
2019
Experimental Determination of Radial Dose Function and Anisotropy Function of GammaMed Plus (192)Ir High-Dose-Rate Brachytherapy Source in a Bounded Water Phantom and its Comparison with egs_brachy Monte Carlo Simulation
J Med Phys
Buchapudi RR, Manickam R, Chandaraj V.
J Med Phys. 2019 Oct-Dec;44(4):246-253. doi: 10.4103/jmp.JMP_60_19. Epub 2019 Dec 11.
2020
Synchronous Lymphomas: An Uncommon Affair
Turk J Haematol
Vidhya M.
Turk J Haematol. 2020 Aug 28;37(3):203-204. doi: 10.4274/tjh.galenos.2019.2019.0187. Epub 2019 Nov 20.
2019
Implementation and Evaluation of Phantomless Intensity Modulated Radiotherapy Delivery Verification Using FractionCHECK
Gulf J Oncolog
Reddy BR, Ravikumar M, Varatharaj C, Childress N, Vivek TR.
Gulf J Oncolog. 2019 Sep;1(31):26-35.
2019
An Assessment of Dosimetric Characteristics of Inline 2.5 Mega Voltage Unflattened Imaging X-Ray Beam
Asian Pac J Cancer Prev
Rajamanickam T, Muthu S, Murugan P, Dinesan C, Mekala C, Senthilnathan K, Arunai Nambi Raj N, Ramesh Babu P.
Asian Pac J Cancer Prev. 2019 Aug 1;20(8):2531-2539. doi: 10.31557/APJCP.2019.20.8.2531.
2019
Studies on Fundamental Interaction Parameters for Stainless Steel and Titanium Biomaterials Using Flattened and Un-Flattened Megavoltage X-Ray Beams
Asian Pac J Cancer Prev
Rajamanickam T, Muthu S, Murugan P, Pathikonda M, Senthilnathan K, Nambi Raj NA, Ramesh Babu P.
Asian Pac J Cancer Prev. 2019 Aug 1;20(8):2485-2491. doi: 10.31557/APJCP.2019.20.8.2485.
2019
The Impact of Breast Cancer on the Patient and the Family in Indian Perspective
Indian J Palliat Care
Alexander A, Kaluve R, Prabhu JS, Korlimarla A, Srinath BS, Manjunath S, Patil S, Gopinath KS, Sridhar TS.
Indian J Palliat Care. 2019 Jan-Mar;25(1):66-72. doi: 10.4103/IJPC.IJPC_158_18.
2019
Practice patterns and outcomes with the use of regorafenib in metastatic colorectal cancer: Results from the Regorafenib in Metastatic colorectal cancer - An Indian exploratory analysis study
South Asian J Cancer
Ramaswamy A, Ostwal V, Pande N, Sharma A, Patil S, Thippeswamy R, Ghadyalpatil N, Roy R, Peshwe H, Poladia B, Rajamanickam D, Rangarajan B, Neelesh Reddy PR, Pandita V, Mukherjee A, Thoke A, Sarkar A, Satish CT, Shashidara H, Banavali SD.
South Asian J Cancer. 2019 Jan-Mar;8(1):22-26. doi: 10.4103/sajc.sajc_173_18.
2018
Follicle-Stimulating Hormone Is an Autocrine Regulator of the Ovarian Cancer Metastatic Niche Through Notch Signaling
J Endocr Soc
Gera S, Kumar S S, Swamy SN, Bhagat R, Vadaparty A, Gawari R, Bhat R, Dighe RR.
J Endocr Soc. 2018 Dec 12;3(2):340-357. doi: 10.1210/js.2018-00272. eCollection 2019 Feb 1.
2018
Study of dosimetric properties of flattened and unflattened megavoltage x ray beam on high Z implant materials
J Appl Clin Med Phys
Rajamanickam T, Muthu S, Murugan P, Pathokonda M, Senthilnathan K, Arunai Nambi Raj N, Ramesh Babu P.
J Appl Clin Med Phys. 2018 Nov;19(6):265-273. doi: 10.1002/acm2.12451. Epub 2018 Sep 28.
2018
Outcomes of Computed Tomography-Guided Image-Based Interstitial Brachytherapy for Cancer of the Cervix Using GEC-ESTRO Guidelines
Indian J Surg Oncol
Rishi KS, Alva RC, Kadam AR, Sharma S.
Indian J Surg Oncol. 2018 Jun;9(2):181-186. doi: 10.1007/s13193-018-0738-6. Epub 2018 Mar 18.
2018
The role of hybrid bone SPECT/CT imaging in the work-up of the limping patient: a symptom-based and joint-oriented review
Eur J Hybrid Imaging
Mohan HK, Strobel K, van der Bruggen W, Gnanasegaran G, Kampen WU, Kuwert T, Van den Wyngaert T, Paycha F.
Eur J Hybrid Imaging. 2018;2(1):8. doi: 10.1186/s41824-018-0026-2. Epub 2018 Apr 23.
2017
Determinants of Tobacco Use and Prevalence of Oral Precancerous Lesions in Cab Drivers in Bengaluru City, India
Int J Prev Med
Shetty P, Khargekar NC, Debnath A, Khargekar NR, Srivastava BK, Hakeen NEF.
Int J Prev Med. 2017 Dec 5;8:100. doi: 10.4103/ijpvm.IJPVM_225_17. eCollection 2017.
2017
Breast Biomarkers-Comparison on Whole Section and Tissue Microarray Section
J Clin Diagn Res
Chavan SS, Ravindra S, Prasad M.
J Clin Diagn Res. 2017 Mar;11(3):EC40-EC44. doi: 10.7860/JCDR/2017/25088.9573. Epub 2017 Mar 1.
2017
HR+HER2- breast cancers with growth factor receptor-mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells
Tumour Biol
Desai K, Aiyappa R, Prabhu JS, Nair MG, Lawrence PV, Korlimarla A, Ce A, Alexander A, Kaluve RS, Manjunath S, Correa M, Srinath BS, Patil S, Kalamdani A, Prasad M, Sridhar TS.
Tumour Biol. 2017 Mar;39(3):1010428317695028. doi: 10.1177/1010428317695028.
2016
Psychosocial and behavioral aspects of populations affected by humanitarian emergencies: recent developments
Curr Opin Psychiatry
Murthy RS.
Curr Opin Psychiatry. 2016 Sep;29(5):280-5. doi: 10.1097/YCO.0000000000000266.
2016
Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer
PLoS One
Korlimarla A, Prabhu JS, Remacle J, Rajarajan S, Raja U, C E A, Srinath BS, Manjunath S, K S G, Correa M, M S N P, Sridhar TS.
PLoS One. 2016 Apr 14;11(4):e0153113. doi: 10.1371/journal.pone.0153113. eCollection 2016.
2016
Vascular endothelial growth factor polymorphisms and a synchronized examination of plasma and tissue expression in epithelial ovarian cancers
Tumour Biol
Bhaskari J, Premalata CS, Shilpa V, Rahul B, Pallavi VR, Ramesh G, Krishnamoorthy L.
Tumour Biol. 2016 Jan;37(1):1017-23. doi: 10.1007/s13277-015-3891-3. Epub 2015 Aug 13.