Sri Shankara Cancer Foundation
At Sri Shankara Cancer Foundation, we firmly believe that the strongest weapon in fighting cancer is the sound understanding and knowledge of cancer. In order to improve this understanding of cancer through a scientific approach, the foundation has set up state of the art research facilities, which undertake cutting edge research in the field of oncology. Sri Shankara Cancer Foundation is recognized by the Department of Scientific and Industrial Research, Government of India as a Scientific and Industrial Research Organization (DSIR - SIRO) and facilitate collaborative efforts of clinicians and scientists in three areas of interest.
BASIC AND TRANSLATIONAL RESEARCH
PREVENTIVE & COMMUNITY ONCOLOGY RESEARCH
The research laboratory is located in our dedicated research block - Sri Sharada Kripa. Spread over an area of 10,000 sq. feet, the state of the art laboratory houses the latest technology in oncological research, including Next Generation Sequencing (NGS), Sanger Sequencer, Real Time PCR (RT-PCR), Fluoroscence In Situ Hybridization (FISH) and Immuno Histo Chemistry (IHC).
The quality control test done for NGS on samples of Lung and Colon cancers at our molecular genetics research laboratory showed that our chip loading density was 94%, 90% on target alignment and mean coverage depth of 3000x.
Our facility has also established a Gastro-Intestinal Bio Bank in collaboration with Institute of Cancer Research, UK - Dr. Sadhanandam's Lab and is also in the process of establishing a Tumour Bio Bank as per the ISBER and ICMR guidelines.
Sri Shankara Cancer Hospital & Research Centre also houses state of the art laboratories that cater to both clinical and academic activities. This includes Biochemistry, Pathology, Microbiology and Virology.
The team at Sri Shankara National Centre for Cancer Prevention and Research are enabled to conduct community, preventive, economic and epidemiological research through customized technology including a custom built, satellite enabled mobile cancer units.
Sri Shankara Cancer Foundation provides a platform for the Clinicians at Sri Shankara Cancer Hospital and Research Centre and Scientists in Sri Shankara National Centre for Cancer Prevention and Research to work together towards improving the outcomes for all cancer patients.
Our faculty list comprises of highly accomplished clinicians and experienced scientists. Students enrolled under various super specialty post graduate programmes are encouraged to actively participate in innovative research.
Sri Shankara Cancer Foundation's efforts towards understanding cancer, improving treatment outcomes and developing interventions to prevent cancer are focused on some of the most common cancers in the Indian population. This includes Ovarian Cancers, Breast Cancers, Gastro-Intestinal Cancers, Lung, Head and Neck Cancers, Urinary Bladder Cancers and Blood cancers (Leukemias and Lymphomas).
With the guidance from eminent academicians and professionals in our Academic Advisory Board and Institutional Ethics Committee, research meetings are held every quarter to evaluate new and ongoing research projects.
On Going Projects
Study on Cardiac Sparing Radiotherapy In Left Breast Carcinoma Patients - Dosimetric Comparison of Various Techniques
Pilot Study of Radiation Dose Escalation In The Treatment of Carcinoma Esophagus undergoing Concurrent Chemoradiation
Clinical pathological profiles of patients with triple negative breast carcinoma
Comparative study of palpation guided lumpectomy, ultrasound guided lumpectomy and cavity shaving technique for attaining negative margins in breast conservation surgery
Comparative Study of Dose to Small Bowel, Bone Marrow and Femur Between 3 Different Radiotherapy Techniques –3D Conformal Radiotherapy (3DCRT), Intensity Modulated Radiotherapy (IMRT) And Rotational Intensity Modulated Radiotherapy in The Treatment of Carcinoma Rectum
Comparison of RENAL, PADUA, ABC and C-index scoring systems in predicting perioperative outcomes after nephron sparing surgery
Prospective Study to compare the efficacy of topical Morphine mouth wash with standard Benzydamine oral mouth wash in the management of Oral mucositis in patients undergoing head and neck radiotherapy or Concurrent chemoradiotherapy
Pilot Study of the Role of Local Consolidative Radiotherapy Following Systemic Chemotherapy on Well Controlled Limited Metastatic Non Small Cell Lung Cancer
Comparison of Salivary Amylase levels, Salivary Scintigraphy and Diffusion Weighted Magnetic Resonance Imaging in evaluation of Xerostomia in Carcinoma of Nasopharynx, Oropharynx, Hypopharynx and Larynx patients treated with Intensity Modulated Radiotherapy
GlobalSurg – CovidSurg week: Determining the optimal timing for surgery following SARS – COV-2 infection
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids
Life Science Alliance
Jimpi Langthasa, Purba Sarkar, Shruthi Narayanan, Rahul Bhagat, Annapurna Vadaparty, Ramray Bhat
Langthasa J, Sarkar P, Narayanan S, Bhagat R, Vadaparty A, Bhat R. Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids. Life Sci Alliance. 2021 Aug 10;4(10):e202000942. doi: 10.26508/lsa.202000942. PMID: 34376568; PMCID: PMC8358442.
Pre-Menopausal Women With Breast Cancers Having High AR/ER Ratios in the Context of Higher Circulating Testosterone Tend to Have Poorer Outcomes
Frontiers in Endocrinology
S Rajarajan A Korlimarla Annie Alexander, C. E. Anupama, R Ramesh, B. S. Srinath5, T. S. Sridhar and JS Prabhu
Front. Endocrinol., 21 June 2021 | https://doi.org/10.3389/fendo.2021.679756
Preliminary clinical outcomes of patients treated with vaginal brachytherapy alone using multi-channel vaginal brachytherapy applicator in operated early-stage endometrial cancer
Rep Pract Oncol Radiother
Rishi KS, David S, Pathikonda M, Ramachandra P, Giri GV, Vadaparty A, Srinath BS.
Rep Pract Oncol Radiother. 2021 Feb 25;26(1):43-49. doi: 10.5603/RPOR.a2021.0007. eCollection 2021.
Single Institution Experience of Postoperative Electron Beam Radiation Therapy in the Treatment of Keloids
Adv Radiat Oncol
Rishi KS, Sarkar N, Kesari P, Pathikonda M, Ramachandra P, Donapati PKR, Giri GV, Srinath BS.
Adv Radiat Oncol. 2020 Oct 21;6(2):100596. doi: 10.1016/j.adro.2020.10.009. eCollection 2021 Mar-Apr.
A comparative study of perioperative techniques to attain negative margins and spare healthy breast tissue in breast conserving surgery
Krishna KL, Srinath BS, Santosh D, Velusamy S, Divyamala KP, Sariya Mohammadi J, Kurpad V, Kulkarni S, Yaji P, Goud S, Dhanireddy S, Ram J.
Breast Dis. 2020;39(3-4):127-135. doi: 10.3233/BD-200443.